Department of Pharmacology, Toxicology & Forensic Medicine

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Department of Pharmacology, Toxicology & Forensic Medicine has more than 7 academic staff members

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Prof.Dr. shaban ahmed kalfallah awidat

shaban awidat هو احد اعضاء هيئة التدريس بقسم أدوية وسموم وطب شرعي بكلية الطب البيطري. يعمل السيد shaban بجامعة طرابلس كـأستاذ منذ 2017-03-15 وله العديد من المنشورات العلمية في مجال تخصصه

Publications

Some of publications in Department of Pharmacology, Toxicology & Forensic Medicine

EFFECT OF SYNCHRONIZATION PROTOCOLS ON HAEMATOLOGICAL AND BIOCHEMICALPARAMETERS IN HEJAZI GOATS

ABSTRACT Background: The objective of this study was to evaluate changes of haematological and biochemical parameters in Hejazi goats under synchronization protocols treatment. Methods:Forty fertile and healthy female Hejazi goats were divided equally and randomly into four groups (n=10). All synchronization protocols started 7 days after the first 125 µg Cloprostenol injection (i.m.). The first group received CIDR treatment for 7 days only and followed by injection of second dose of PGF2α and 400 IU of PMSG, and the second group received CIDR treatment for 14 days and followed by injection of second dose of PGF2α and 400 IU of PMSG, and the third group received injection of 0.004 µg of synthetic GnRH analogue for 7 days and followed on day 14 by a second injection of 125 µg PGF2α followed by second injection of 0.004 µg of synthetic GnRH analogue, the fourth group received two doses of 125 µg PGF2α with14 days interval. Blood samples were collected from all of the does for biochemical analysis. Results: Observations showed no external or behaviour changes recorded and slight changes in all groups in diagnostic parameters. The conception rate tended to be decrease specific with increase in other days Conclusions: This study showed that monitoring the biochemical diagnostic parameters in the four groups going different protocols we didn’t record any significant different (P>0.05). The current study suggests that CIDR treatment for short and long are safe in Hejazi doe
Marwan M. Draid, Abdurraouf O. Gaja, Hoda R. Shnaishah(6-2021)
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NANC inhibitory neuromuscular transmission in the hamster distal colon

The neurotransmitter(s) that generate the inhibitory junctional potential (IJP) in the circular muscle of hamster distal colon and their mechanisms have not been elucidated. The aim of the present study, therefore, was to determine the contributing roles of the non-adrenergic, non-cholinergic (NANC) inhibitory transmitter(s) including nitric oxide (NO), adenosine 5′-triphosphate (ATP) and vasoactive intestinal polypeptide (VIP) in the generation of IJP in the hamster distal colon. For this purpose, the effects of the corresponding blockers of these putative NANC inhibitory mediators have been investigated using microelectrode technique. arabic 8 English 62
M. Draid(12-2006)
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Environmental Conditions Responsible for Hibernation in Mammals

抄録 地球環境の温暖化によって,野生動物の繁殖や冬眠行動が大きな影響を受けることは容易に想像できる。しかし,実際に冬眠がどのような環境条件に影響されているのかは不明である。そこで,本研究では,冬眠行動を誘発する環境条件について検討を行った。冬眠する齧歯目として知られているシリアンハムスターをモデルとして用いた。冬眠の誘発にとって,気温の低下と日照時間の短縮は最も重要な要因であると考えられる。そこで,ハムスターを恒暗・低温環境下で飼育したところ,冬眠に入った。一方,これらの条件に加えて,飼料としてヒマワリの種子や高脂肪食を充分に与えたのち,給餌制限を行った場合,自由摂食をさせた個体と比較して,短期間で冬眠状態に入ることが見いだされた。このことは,食物の量と組成も冬眠行動の誘発に深く関連することを示唆するものである。また,これまでの実験結果から,体重の大きい個体ほど冬眠に入りやすいことがわかった。このことは,体内に蓄積された脂肪細胞から分泌されるレプチンなどのホルモンが,冬眠行動と関連する可能性を示唆するものである。これらの結果から,冬眠は,環境温度や日照時間,そして食物といった外部環境の変化と関連することが示唆された。 It is considered that global warming and exposure to endocrine disrupting chemicals can influence reproduction and hibernation of wildlife. However, environmental factors responsible for such behavioral differences are not well recognized. Therefore, in this study we analyzed environmental conditions that are critical for inducing hibernation. Non-seasonal hibernators, Syrian hamsters were used in this study. It has been pointed out that a low environmental temperature is an important factor to induce hibernation. So, hamsters were kept at a cold room. After about two or three months, they hibernated. Next, food restriction under the cold environment was performed. When the hamsters were fed sunflower seeds or high fat food not standard laboratory chow and then food supply was restricted, they efficiently hibernated in a shorter time period compared with those which were given free access to food. This suggests that the quantity and nutritional composition of food can affect hibernating behavior in addition to a low environmental temperature. We noticed that hibernation is more efficiently induced in obese hamsters than in thin ones. This may indicate that hormones derived from adipose tissue including leptin could be related to hibernation. These results suggest that hibernation might be associated with external environmental factors (environmental temperature and food composition). arabic 6 English 57
Marwan Draid(3-2007)
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