Accumulating evidence indicates the role of endocrine disruptor bisphenol A (BPA) in many pathological conditions. Histone deacetylase (HDAC) inhibition has potential for the treatment of many diseases/abnormalities. Using a mouse BPA exposure model, this study investigated the hepatoprotective effects of the Food and Drug Administration–approved HDAC2 inhibitor valproic acid (VPA) against BPA-induced liver pathology. We randomly divided 30 adult male Swiss albino mice (8 weeks old; N = 6) into five groups: group 1, no treatment (sham control (SC)); group 2, only oral sterile corn oil (vehicle control (VC)); group 3, 4 mg/kg/day of oral BPA (single dose (BPA group)); group 4, 0.4% oral VPA (VPA group); and group 5, oral BPA + VPA (BPA + VPA group). At the age of 10 weeks, the mice were euthanized for biochemical and histological examinations. BPA promoted a significant decrease in the body weight (BW), an increase in the liver weight, and a significant increase in the levels of liver damage markers aspartate aminotransferase and alanine aminotransferase in the BPA group compared to SC, as well as pathological changes in liver tissue. We also found an increase in the rate of apoptosis among hepatocytes. In addition, BPA significantly increased the levels of oxidative stress indices, malondialdehyde, and protein carbonylation but decreased the levels of reduced glutathione (GSH) in the BPA group compared to SC. In contrast, treatment with the HDAC2 inhibitor VPA significantly attenuated liver pathology, oxidative stress, and apoptosis and also enhanced GSH levels in VPA group and BPA + VPA group. The HDAC2 inhibitor VPA protects mice against BPA-induced liver pathology, likely by inhibiting oxidative stress and enhancing the levels of antioxidant-reduced GSH.
Mohamed A. Al-Griw, Zaynab Osama Alshibani, Rabia Omar abdullah Alghazeer, Mohamed Elhensheri, Refaat. M. Tabagh, Areej A. Eskandrani, Wafa S. Alansari, Mahmoud M. Habibulla, Ghalia Shamlan(6-2022)

Abstract Mixed chromium oxides with some divalent metals such as Fe, Co, Ni, Zn,Cd and Hg were prepared by two ways:- Coprecipitation of carbonates of the intended metals then calcination of the precipitates. Calcination of ground mixtures of oxy salts that are easilydecomposable.The produced mixed oxides were characterized using X- ray diffraction and the results were matched with those of A.S.T.M (Americation society of testing materials) and agreement was observed with the patterns of the intended compounds. The particle size was calculated from the profile of the diffraction peaks. Thermal behavior (TGA and DTA) was investigated and the thermodynamics and kinetics factors were calculated. The D.C. electrical conductivity was measured at room temperature and higher temperatures from where the activation energy of conduction was calculated. The materials prepared proved to behave as semiconductors in the investigated range of temperature.
حنان علي عبد السلام الشنطة (2009)

Abstract Five symmetrical Schiff base ligands[four bi-dentate and one tetradentate(L3- L7)] and two un-symmetrical bi-dentate and tri-dentate (L1-L2) ligands with the Nitrogen and oxygen chromophore were isolated inpure form and good yield. The ligands were fully characterized by elemental analyses, melting point, IR, H1- &13C- NMR, and mass spectra.The Schiff bases L1 and L2 were successfully coordinated to Pd(II) and VO2+ ions respectively and these complexes were characterized using elemental analyses, IR and mass spectra. The interesting result by mass spectrum of VO2+ complex of L2 shows parent peak at 524 confirming that the formula of the complex as [VOL2(ac.ac.)2H2O] in which the complex has an octahedral geometry.The symmetrical Schiff bases (L3-L7) were also successfully coordinated to Nickel (II), Copper (II), Lead (II), Cadmium (II), and Mercury (II) ions to form their corresponding complexes. The total twenty five metal (II) XI Schiff base complexes of (L3-L7) were isolated. These complexes were characterized by elemental analyses, melting points, IR, mass spectra technique. 1H &13C-NMR Spectra in DMSO d6 for Pb, Cd, and Hg complexes show the expected number of peaks with deferent chemical shift comparing with the free ligands in the same solvent. The interesting result by mass spectrum of Ni(L7)2 complex compred with of L7 spectra shows parent peak at 977 confirming that the ligand L7 has lost one proton to give the desire complex in square planar geometry.
حميدة أحمد سالم العباني (2015)